Blood

1. Introduction
   1. Background
   2. Functions
      1. transportation
      2. maintenance & homeostasis
      3. defense
   3. Composition
      1. connective tissue
         1. formed elements
         2. plasma
      1. plasma
      2. buffy coat
      3. erythrocytes
         1. hematocrit
   4. Physical Characteristics
2. Blood Plasma
   1. Description
   2. Function
   3. Contents
      1. proteins
         1. albumins
         2. globulins
            1. immunoglobulins
         3. fibrinogen
      2. non-protein
3. Formed elements
   1. hematopoiesis
   1. Erythrocytes
      1. structural
      2. function
         1. hemoglobin
            1. heme
      3. measuring
         1. hypoxemia
      4. production & destruction
         1. erythropoiesis
            1. erythropoietin
         2. at the end of their useful life
            1. biliverdin
            2. bilirubin
      5. disorders
         1. anemia
         2. jaundice
         3. bruise
         4. sickle cell disease
         5. polycythemiaLeukocytes
      6. structure
      7. function
      8. categories
         1. granulocytes
         2. agranulocytes
   2. Platelets
      1. megakaryocytes
      2. structure
      3. function
      4. thrombopoietin
      5. thrombocytosis
      6. thrombocytopenia
4. Blood Clotting
   1. Vascular spasm
   2. Platelet plug formation
   3. Coagulationa
      1. plasma clotting factors
      1. extrinsic pathway
         1. thromboplastin
      2. intrinsic pathway
         1. platelets
      3. common pathway
         1. Factor X
         2. prothrombin to thrombin
         3. fibrinogen to fibrin
            1. clot
            2. retraction
               • serum
   4. Fibrinolysis
      1. plasminogen
      2. tissue plasminogen activator (TPA)
      3. plasmin
5. Clotting disorders
   1. Too much clotting
      1. thrombus
      2. embolus
         1. embolism
   2. not enough clotting
      1. thrombocytopenia
      2. hemophilia
6. Blood typing
   1. A, B, AB, O
   2. Rh
   3. Transfusion Reactions
      1. antibodies
      2. agglutination
      3. hemolysis
      4. hemolytic disease of the newborn (HDN)