1. interstitial fluid
2. Lymphatic system

1. Lymphatic capillaries
   1. lymph
2. Lymphatic vessels
3. Lymphatic trunks
4. Lymphatic ducts
   1. right lymphatic duct
   2. thoracic duct

Innate Immunity

1. First line defenses
   1. Physical barriers
      1. skin
      2. mucous membranes
      3. saliva
      4. stomach
   2. Chemical Factors
      1. sebum
      2. salt
      3. lysozyme
2. Normal Flora

1. Hematopoietic stem cell
2. Erythrocyte
3. Megakaryocyte
   1. Platelets
4. White Blood Cells = Leukocytes
   1. Granulocytes
      1. Eosinophils
      2. Basophils
      3. Neutrophils
      4. Mast cells
   2. Agranulocytes
      1. Monocytes
         1. macrophages
         2. dendritic cells
   3. Lymphocytes
      1. groups
         1. B lymphocytes
         2. T lymphocytes
         3. Natural killer (NK) cellsCell Communication
5. Cytokines
6. receptors
   1. Chemokines
   2. Colony-stimulating factors (CSF)
   3. Interferons (IFNs)
   4. Interleukins (ILs)
   5. Tumor necrosis factors (TNFs)

1. Phagocytes
2. Process
   1. adherence
   2. ingestion
      1. pseudopods
      2. phagosome
      3. phagolysosome

1. Pattern Recognition Receptors (PRRs)
2. Complement System
   1. C3b
   2. membrane attack complex (MAC)

1. Signs
2. Purpose
3. Process
   1. vasodilation
   2. leukocyte capture
      1. adhesion molecules
      2. Tumbling
      3. diapedesis
   3. pus
4. Hallmarks
   1. acute inflammation
   1. chronic inflammation
5. Outcomes
   1. septic shock

1. Epitope

1. Immunoglobulin (Ig)
2. Structure
   1. Side to side
      1. Heavy chains
      2. Light chains
   2. Top to Bottom
      1. Function
         1. Fab
         2. Fc
      2. Sequence
         1. variable region
         2. constant region
3. Classes
   1. IgM
      1. pentamer
      2. first produced
   2. IgG
      1. 80% of circulating Abs
      2. longest half life
      3. cross placenta
      4. colostrum
   3. IgA
      1. most Ig class produced
      2. dimer
   4. IgD
      1. ?
   5. IgE
      1. mast cells
         1. allergic response

1. Diversity
2. Development
3. Selection
   1. positive selection
   2. negative selection
   3. T lymphocytes
      1. thymus
   4. B lymphocytes
4. Lymphoid tissue
   1. lymph nodes
   2. spleen
   3. tonsils
   4. appendix
   5. MALT
   6. BALTAb production
5. Exogenous Ags
6. B lymphocytes
   1. process
      1. bind
      2. internalize
      3. process
      4. present
      5. wait
7. T-Helper cells - T-Dependent Ags
   1. CD-4
   1. B cell Primary response
      1. clonal selection
      2. differentiation
         1. plasma cells
            1. titer
      3. class switching
      4. affinity maturation
      5. when win
   2. Secondary Response
      1. memory B cells
8. T-Independent Ag

1. Neutralization
2. Immobilization
3. Agglutination & Precipitation
4. Opsonization
5. Complement activation
6. ADCC

1. Endogenous Ags
   1. MHC class I
   2. cytotoxic T cell
      1. CD 8
         1. porforin
         2. granzymes
2. Viral infection
   1. NK cells