Eicosanoids

1. Background
   1. arachidonic acid (AA)
      1. phospholipase A2
   2. paracrine
2. Prostaglandins
   1. History
   2. Description
   3. Function
   4. cyclooxygenase
      1. prostaglandin H2 (PGH2)
   5. Blocking cyclooxygenase - two isoforms of cox - 60-65% homologous at aa level
      1. cox 1
      2. cox 2
      3. aspirin
      4. cox 2 inhibitors
3. Thromboxanes
   1. Description
   2. Function
   3. Synthesis
      1. thromboxane synthase
4. Prostacyclins
   1. Description
   2. Function
   3. Synthesis
      1. prostacyclin synthase
5. Leukotrienes
   1. Description
   2. Function
   3. Synthesis
      1. leukotriene synthase
   4. Actions