B cell Activation and Ab Production Chapter 12

1. Ag Binding and Presentation
   1. Bind
   2. Internalize
   3. Process
   4. Present
   5. Wait
2. B cell Interaction with Th cells
   1. T cells
   2. Meeting
   3. Confirmation
      1. binding
      2. CD40-CD40L interaction
      3. cytokines
      4. Tfh
         1. IL-21
3. B cell Responses
   1. Proliferation
   2. Affinity maturation
      1. somatic hypermutation
         1. AID
      2. selection
      3. repeat
   3. Heavy chain isotype (class) switching
      1. overview
      2. examples
      3. Switch region (S)
      4. switch recombination
         1. AID
         2. UNG
         3. APE1
      5. result
4. T-independent Ab Response
   1. Ag
   2. Results
5. Results of B cell Differentiation
   1. plasma cells
   1. Short lived plasma cells
   2. Long lived plasma cells
      1. plasmablasts
   3. Memory B cells