Functions of CD8⁺ Effector T Cells Chapter 11

1. Introduction
2. Differentiation
   1. Activation
      1. signal
         1. B7
         2. CD28
      2. signal
         1. cytokines
      3. signal
         1. CD40L - CD40
      4. licensing
   2. Effectorization
3. CD8⁺ Effector Functions
   1. Synapse formation
   2. Killing
      1. overview
      2. granules
      3. contents
         1. perforin
         2. granzymes
            1. apoptosis
         3. granulysin
      4. FAS-L
         1. FAS
   3. Protection
      1. cathepsin B
      2. serine proteinase inhibitor
4. Exhaustion
   1. repeated stimulation
   2. Chronicity
5. Memory CD8⁺ T cells