Innate Immunity Chapter 4

1. Background
   1. Innate
   2. What do
   3. Advantages & disadvantages
2. External Barriers
   1. Skin
   2. Mucus
   3. Other washing action
   4. Antimicrobial peptides in secretions
      1. lactoperoxidase
      2. lysozyme
      3. defensins
      4. collectins
      5. cathelicidin
      6. SLPI
   5. Gastric pH
   6. Normal flora
   7. Tissue resident sentinel cells
3. Phagocytosis
   1. Process
      1. phagosome
      2. phagolysosome
   2. Recognition
      1. PAMPs
      2. DAMPs
         1. alarmins
      3. PRRs
         1. Toll-like receptors
            1. name
            2. protein structure
            3. cell surface
            4. lysosomal
         2. NOD-like receptors
            1. structure
            2. subfamilies
            3. examples
               • gout
         3. RIG-like receptor
         4. CDS
         5. Lectin receptors
   3. Killing
      1. reactive oxygen species (ROS)
      2. nitric oxide
      3. proteolytic enzymes
      4. Humoral Mechanisms
   4. Complement
      1. alternative pathway
         1. C3
         2. C3b
         3. MAC
      2. additional Complement activities
         1. opsonization
      3. released fragments
   5. Pentraxins
      1. CRP
   6. Collectins
      1. structure
      2. family members
         1. MBL
         2. surfactant protein A & D
   7. Ficolins
      1. structure, action
4. Inflammation
   1. Signs
   2. Purpose
   3. Initiation
   4. Process
      1. vasodilation
         1. permeability
      2. leukocyte recruitment
         1. adhesion molecules
            1. ICAM-1
            2. selectins
         2. tumbling
         3. integrins
         4. diapedesis
      3. pus
   5. Hallmarks
      1. localized
         1. acute inflammation
      2. healing
      3. chronic inflammation
   6. Outcomes
5. Antiviral
   1. Interferons
      1. family, source, actions
   2. NK cells
      1. function / detection
      2. killing
         1. perforin
         2. granzymes -> apoptosis
6. Fever
7. Stimulating Adaptive Immune Responses
   1. adjuvants
   1. Costimulators
   2. Cytokines
   3. Complement