Antimicrobial Treatment Chapter 10 I. Vocabulary A. Prophylaxis B. Antimicrobial Chemotherapy C. Antimicrobials D. Antibiotics E. Semisynthetic F. Synthetic G. Narrow-Spectrum H. Broad-Spectrum II. Antimicrobial Considerations III. History A. Salvarsan B. Sulfonamides C. Penicillin D. Now others IV. Diagnosis V. Discovery & Susceptibility A. Evaluation B. Use-dilution test C. Tube-dilution test D. Kirby-Bauer a. zone if inhibition VI. Antimicrobial classes A. Target = Cell wall 1. Penicillins 2. Cephalosporins 3. Vancomycin B. Target - Protein synthesis 1. Aminoglycosides 2. Tetracycline 3. Macrolides C. Target - folic acid synthesis 1. Sulfonamides D. Target - DNA 1. Fluoroquinolones VII. Anti-fungals VIII. Anti-protozoals A. Metronidazole IX. Anti-virals A. Strategies X. Antimicrobial Resistance A. Intrinsic B. Acquisition C. Mechanisms