Innate Immunity Chapter 16

1. Definitions
   1. Innate (Natural) Immunity
   2. Adaptive Immunity
2. Non-Specific Host Defenses
   1. First line defenses
      1. Physical barriers
         1. skin
         2. mucous membranes
         3. saliva
      2. Chemical Factors
         1. sebum
         2. salt
         3. lysozyme
   2. Normal Flora
3. Formed Elements
   1. Hematopoietic stem cell
   2. Erythrocyte
   3. Megakaryocyte
      1. Platelets
   4. White Blood Cells = Leukocytes
      1. Granulocytes
         1. Eosinophils
         2. Basophils
         3. Neutrophils
      2. Agranulocytes
         1. Monocytes
            1. macrophages
            2. Dendritic cells
         2. Lymphocytes
         3. Natural killer (NK) cells
4. Cell Communication
   1. Cytokines
      1. receptors
   2. Examples
      1. Chemokines
      2. Colony-stimulating factors
      3. Interferons
      4. Interleukins
      5. Tumor necrosis factors
   3. Adhesion molecules
5. Phagocytosis
   1. Phagocytes
   2. Process
      1. adherence
      2. ingestion
         1. pseudopods
         2. phagosome
      3. phagolysosome
6. Inflammation
   1. Signs
   2. Purpose
   3. Process
      1. Dilation
      2. Leukocyte migration
         1. Tumbling
         2. diapedesis
      3. pus
   4. Hallmarks
      1. acute inflammation
      2. chronic inflammation
   5. Outcomes
      1. sepsis
7. Fever
8. Sensor Systems
   1. Toll-Like Receptors
   2. Complement System
      1. Classical pathway
      2. Alternative pathway
         1. C3b
         2. membrane attack complex (MAC)