Antihypertensives Chapter 17

1. Physiology Background
   1. Hypertension
   2. Levels of control
2. Vascular resistance modifiers
   1. Physiology pathway
      1. angiotensinogen
      2. juxtaglomerular cells
      3. renin
      4. angiotensin I
      5. ACE
      6. angiotensin II
         1. actions
      7. AT1
      8. Ca⁺⁺ channels
   2. Renin inhibitor
      1. Aliskiren (Tekturna)
   3. ACE inhibitors
      1. action
      2. pharmacokinetics
      3. adverse effects
      4. drugs
         1. Captopril (Capoten)
         1. Lisinopril (Prinivil, Zestril)
         2. Enalapril (Vasotec)
         3. Quinapril (Accupril)
   4. ARBs
      1. Losartan (Cozaar)
      2. Valsartan (Diovan)
   5. Ca⁺⁺ channel blockers
      1. Classes
         1. Verapamil (Calan, Isoprin, Verelan)
         2. Diltiazem (Cardizem, Cartia, Dilacor)
         3. Amlodipine (Norvasc)
      2. Actions
3. Cardiac output modification
   1. Background
   2. Andrenergic receptors
      1. classes
   3. a-blockers
   4. b-andrenoceptor-blocking agents
      1. Propanolol (Inderal, Innopran)
      2. cardio selective
         1. Atenolol (Tenormin)
         2. Metoprolol (Lopressor, Toprol-XL)
         3. Nebivolol (Bystolic)
      1. Adverse effects