Migraine Treatments

1. Background
   1. Types of headaches
   2. Migraines
      1. types
         1. without aura
         2. with aura
      2. physiology
   3. Management / Treatment
      1. avoid triggers
      2. abortive treatments
      3. prophylactic therapy
2. Migraine Abortive Treatments
   1. NSAIDs
   2. Serotonin agonists
      1. serotonin background
         1. discovery
         2. location
         3. effects
         4. synthesis
         5. receptors
      2. Triptans
         1. drugs
            1. sumatriptan (Imitrex, Onzetre, Zembrace)
            2. eletriptan (Relpax)
            3. rizatriptan (Maxalt, Maxalt-MLT)
            4. zolmitriptan (Zomig)
   3. Ergot alkaloids
      1. ergotamine (Ergomar)
      2. dihydroergotamine (DHE 45, Migranal)
   4. CGRP receptor antagonists
      1. background
      2. receptor antagonist
         1. ubrogepant (Ubrelvy)
         2. rimegepant (Nurtec)
   5. OpioidsMigraine Prophylaxis Treatments
   6. b-blockers
      1. propranolol (Inderal LA, Innopran XL)
   7. Anticonvulsants
      1. topirmate (Topamax)
      2. valproic acid (Valproate)
   8. Other
   9. CGRP
      1.  CGRP itself
         1. monoclonal antibodies
            1. fremanezumab (Ajovy)
            2. galcanezumab (Emgality)
            3. eptinezumab (Vyepti)
      2. block receptor
         1. monoclonal Ab
            1. erenumab (Aimovig)
         2. receptor antagonist
            1. rimegepant (Nurtec)
            2. atogepant (Qulipta)
   10. Antidepresents
       1. tricyclic antidepressants
          1. amitriptyline (Elavil, Endep, Vanatrip)
          2. nortriptyline (Pamelor)
       2. SNRI
          1. venlafaxine (Effexor ER, Effexor)
       3. SSRI
          1. fluoxetine (Prozac, Sarafem, Rapiflux, Selfemra)
3. Tension Headaches
4. Cluster Headaches